To attempt a phylogenetic analysis of the sequences so as to construct evolutionary trees the identification of functional sites the identication of modules in multimodular protein the identification of motifs the detection of weak similarities in databases using profiles the design of PCR primers for the identification of related genes Of sequences, either protein or nucleotide, which exhibit significant similarity and are inferred to be homologous These sequences can then be subjected to multiple sequence alignment The process that involves an attempt to place residues in columns that derive from a common ancestral residue by substitutions The most successful alignment is the one that most closely represents the evolutionary history of the sequencesĤ Why create multiple sequence alignments? Sorry, your browser doesn't support embedded videos.2 AIMS To introduce the different approaches to multiple sequence alignment To identify criteria for selecting a multiple sequence alignment program OBJECTIVES To select an appropriate multiple sequence alignment program To carry out a multiple sequence alignment using CLUSTALXģ The result of searching databases is the establishment of a list Note that some files are not compatible with universal file viewers and can only be opened in binary format. These programs can open many different types of files, so if none of the above tips work, a universal file viewer is the way to go. When no other program will open your ALN file, universal file viewers like File Magic (Download) are here to save the day. If you can’t open your ALN file using any of the usual programs, you can contact the program’s software developer and ask them for help.įind your program’s developer in the list below: Nobody knows more about file extensions than software developers. Just right-click the file icon and select “Properties” or “More Info.” On a Windows computer, the file type will be listed under “Type of File” on a Mac, it will be under “Kind.” Contact a Developer You can find out which type of file your ALN file is by looking at the file’s properties.

Viewer for clustal .aln files for mac